Issue 47, 2023

Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

Abstract

We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.

Graphical abstract: Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

Supplementary files

Article information

Article type
Communication
Submitted
09 رمضان 1444
Accepted
26 شوال 1444
First published
27 شوال 1444

Chem. Commun., 2023,59, 7240-7242

Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

K. E. Grier, A. H. Hansen, C. S. Haxvig, X. Li, O. Krigslund, N. Behrendt, L. H. Engelholm, F. Rossi, B. C. Sousa, G. J. Harradence, N. Camper and K. M. Qvortrup, Chem. Commun., 2023, 59, 7240 DOI: 10.1039/D3CC01596C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements