Issue 43, 2023

An efficient metal-free desulfurization strategy promoted by Togni-II reagent

Abstract

Desulfurization is a versatile synthetic tool in organic synthesis, particularly in peptide chemistry, where it offers an effective conversion strategy for compounds that contain mercaptan groups. In this study, we present a metal-free desulfurization method for amino acids and peptides using a Togni-II reagent as a radical initiator. Our method showed excellent efficiency and extensive substrate tolerance, circumventing the formation of radical adducts caused by VA-044. The obtained results further expand the applicability of Togni-II reagent as a key promotor in radical-based reactions.

Graphical abstract: An efficient metal-free desulfurization strategy promoted by Togni-II reagent

Supplementary files

Article information

Article type
Communication
Submitted
07 رمضان 1444
Accepted
07 شوال 1444
First published
07 شوال 1444

Chem. Commun., 2023,59, 6513-6516

An efficient metal-free desulfurization strategy promoted by Togni-II reagent

J. Zhang, H. Liu, S. Teng, Z. Liao, L. Meng, Q. Wan and S. Dong, Chem. Commun., 2023, 59, 6513 DOI: 10.1039/D3CC00983A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements