Issue 19, 2023

Directed C8–H allylation of quinoline N-oxides with vinylcyclopropanes via sequential C–H/C–C activation

Abstract

The Rh(III)-catalyzed C8-allylation of quinoline N-oxides has been accomplished using vinylcyclopropanes as an allyl source with excellent diastereoselectivity at room temperature. The CH/CC activation, substrate scope and natural product mutation are the important practical features.

Graphical abstract: Directed C8–H allylation of quinoline N-oxides with vinylcyclopropanes via sequential C–H/C–C activation

Supplementary files

Article information

Article type
Communication
Submitted
12 جمادى الأولى 1444
Accepted
17 رجب 1444
First published
18 رجب 1444

Chem. Commun., 2023,59, 2823-2826

Directed C8–H allylation of quinoline N-oxides with vinylcyclopropanes via sequential C–H/C–C activation

S. Mandal, P. Karjee, S. Saha and T. Punniyamurthy, Chem. Commun., 2023, 59, 2823 DOI: 10.1039/D2CC06646G

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