Issue 40, 2022

Polyethyleneimine-based immunoadjuvants for designing cancer vaccines

Abstract

Despite extensive efforts to improve the effectiveness of cancer vaccines, the lack of immunogenicity remains an issue. Adjuvants are required to enhance the immunogenicity of antigens and activate the immune response. However, only a few adjuvants with acceptable toxicity have sufficient potency for use in cancer vaccines, necessitating the discovery of potent adjuvants. The most well-known cationic polymer polyethyleneimine (PEI) acts as a carrier for delivering antigens, and as an immunoadjuvant for enhancing the innate and adaptive immunity. In this review, we have summarized PEI-based adjuvants and discussed how to improve and boost the immune response to vaccines. We further focused on PEI-based adjuvants in cancer vaccines. Finally, we have proposed the potential challenges and future issues of PEI-based adjuvants to elicit the effectiveness of cancer vaccines.

Graphical abstract: Polyethyleneimine-based immunoadjuvants for designing cancer vaccines

Article information

Article type
Review Article
Submitted
29 ذو القعدة 1443
Accepted
25 صفر 1444
First published
15 ربيع الأول 1444

J. Mater. Chem. B, 2022,10, 8166-8180

Polyethyleneimine-based immunoadjuvants for designing cancer vaccines

X. Yang, Y. Wei, L. Zheng, J. You, H. Li, L. Gao, C. Gong and C. Yi, J. Mater. Chem. B, 2022, 10, 8166 DOI: 10.1039/D2TB01358D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements