Issue 38, 2022

Nanotechnology-integrated ferroptosis inducers: a sharp sword against tumor drug resistance

Abstract

Presently, the biggest hurdle to cancer therapy is the inevitable emergence of drug resistance. Since conventional therapeutic schedules fall short of the expectations in curbing drug resistance, the development of novel drug resistance management strategies is critical. Extensive research over the last decade has revealed that the process of ferroptosis is correlated with cancer resistance; moreover, it has been demonstrated that ferroptosis inducers reverse drug resistance. To elucidate the development and promote the clinical transformation of ferroptosis strategies in cancer therapy, we first analyzed the roles of key ferroptosis-regulating molecules in the progression of drug resistance in-depth and then reviewed the design of ferroptosis-inducing strategies based on nanotechnology for overcoming drug resistance, including glutathione depletion, reactive oxygen species generation, iron donation, lipid peroxidation aggregation, and multiple-drug resistance-associated tumor cell destruction. Finally, the prospects and challenges of regulating ferroptosis as a therapeutic strategy for reversing cancer therapy resistance were evaluated. This review aimed to provide a comprehensive understanding for researchers to develop ferroptosis-inducing nanoplatforms that can overcome drug resistance.

Graphical abstract: Nanotechnology-integrated ferroptosis inducers: a sharp sword against tumor drug resistance

Article information

Article type
Review Article
Submitted
28 ذو القعدة 1443
Accepted
23 محرم 1444
First published
24 محرم 1444

J. Mater. Chem. B, 2022,10, 7671-7693

Nanotechnology-integrated ferroptosis inducers: a sharp sword against tumor drug resistance

C. Li, X. Wu, C. Zheng, S. Xu, Y. Liu, J. Qin, X. Fan, Y. Ye and W. Fei, J. Mater. Chem. B, 2022, 10, 7671 DOI: 10.1039/D2TB01350A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements