Issue 19, 2022

Natural product total synthesis using rearrangement reactions

Abstract

Total synthesis of natural products has been an important pursuit in chemical synthesis due to their fascinating structural complexity and/or interesting biological activities. In most synthetic designs, the rapid construction of the core skeletons, the precise control of stereochemistry, and the identification of suitable synthons are key concerns, which, to a large extent, account for the overall synthetic efficiency. This review will highlight how rearrangement reactions can contribute in addressing these three concerns, thus simplifying the total synthesis campaigns.

Graphical abstract: Natural product total synthesis using rearrangement reactions

Article information

Article type
Review Article
Submitted
02 ذو الحجة 1443
Accepted
07 محرم 1444
First published
08 محرم 1444

Org. Chem. Front., 2022,9, 5383-5394

Natural product total synthesis using rearrangement reactions

L. Chen, G. Li and L. Zu, Org. Chem. Front., 2022, 9, 5383 DOI: 10.1039/D2QO01040B

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