Issue 2, 2022

Synthesis of amidines via iron-catalyzed dearomative amination of β-naphthols with oxadiazolones

Abstract

An iron-catalyzed dearomative amination of β-naphthols via a nitrene-transfer process has been developed. Oxadiazolones, which have rarely been applied for the synthesis of amidines, are used as the nitrene source. A variety of amidines bearing β-naphthalenone moieties were generated smoothly in good to high yields (up to 98%) in the presence of 1.5 equivalents of tetrabutylammonium bromide, which was added as an essential additive.

Graphical abstract: Synthesis of amidines via iron-catalyzed dearomative amination of β-naphthols with oxadiazolones

Supplementary files

Article information

Article type
Research Article
Submitted
03 ربيع الثاني 1443
Accepted
23 ربيع الثاني 1443
First published
25 ربيع الثاني 1443

Org. Chem. Front., 2022,9, 380-385

Synthesis of amidines via iron-catalyzed dearomative amination of β-naphthols with oxadiazolones

Y. Fan, X. Guan, W. Li, C. Lin, D. Bing, M. Sun, G. Cheng, J. Cao, J. Chen and Q. Deng, Org. Chem. Front., 2022, 9, 380 DOI: 10.1039/D1QO01687C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements