Issue 38, 2022

Achieving regioselective materials binding using multidomain peptides

Abstract

The ability to integrate two disparate materials-binding domains into a single ligand to achieve regiospecific binding would be powerful to direct material assembly; however, this has proven challenging to achieve due to cross-materials binding. Accomplishing this goal might be achieved by harnessing the precision of biology to exploit the recognition between peptides and specific nanomaterials. Here, a designed bifunctional molecule termed Biomolecular Exfoliant and Assembly Motifs (BEAM) is introduced, featuring two different materials-binding peptide domains, one for graphene and one for hexagonal boron nitride (h-BN), at each end of the molecule, separated by a fatty acid spacer. The BEAM is demonstrated to bind strongly to both graphene and h-BN surfaces, and in each case the materials-binding peptide domain is shown to preferentially bind its target material. Critically, the two materials-binding domains exhibited limited cross-domain interaction. The BEAM design concept shows substantial potential to eventually guide self-organization of a range of materials in aqueous media.

Graphical abstract: Achieving regioselective materials binding using multidomain peptides

Supplementary files

Article information

Article type
Paper
Submitted
09 ذو القعدة 1443
Accepted
03 صفر 1444
First published
12 صفر 1444

Nanoscale, 2022,14, 14113-14121

Author version available

Achieving regioselective materials binding using multidomain peptides

R. Jin, N. Brljak, R. Sangrigoli, T. R. Walsh and M. R. Knecht, Nanoscale, 2022, 14, 14113 DOI: 10.1039/D2NR03169H

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