Issue 75, 2022

Synergistically activated dual-locked fluorescent probes to monitor H2S-induced DNA damage

Abstract

Naphthalimide-based fluorescent probes (NAN0-N3 and NAN6-N3) were developed with dual locked fluorescence. Here, ≥1.9 × 10−2 mM of H2S and ≥2.2 × 10−2 μg mL−1 of DNA could unlock a highly sensitive off–on fluorescence response through synergistic changes of the molecular structure and conformation. As such, the probes could monitor DNA damage induced by the overexpression of H2S, and were able to evaluate the degree of apoptosis of living cells mediated by H2S-induced mtDNA or nDNA damage.

Graphical abstract: Synergistically activated dual-locked fluorescent probes to monitor H2S-induced DNA damage

Supplementary files

Article information

Article type
Communication
Submitted
30 ذو الحجة 1443
Accepted
25 محرم 1444
First published
04 صفر 1444

Chem. Commun., 2022,58, 10500-10503

Synergistically activated dual-locked fluorescent probes to monitor H2S-induced DNA damage

Y. Wang, X. Zhao, Y. Chen, T. D. James, G. Wang and H. Zhang, Chem. Commun., 2022, 58, 10500 DOI: 10.1039/D2CC04247A

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