Issue 67, 2022

Directional migration propensity of calf thymus DNA in a gradient of metal ions

Abstract

Herein we report the migrational behaviour and spatial distribution of calf thymus DNA in a gradient of different physiologically relevant monovalent and divalent cations under two different conditions – (i) microfluidic and (ii) evaporating droplets. Amplified phoresis toward high concentrations of Mg2+ and Ca2+ compared to other ions and non-uniform DNA coating in a gradient of ions were observed. This process, which was governed by the effective charge and diffusion coefficient of the DNA–metal ion complex, can have potential applications in nucleic acid-based spatiotemporal surface patterning, biosensors, and dynamic biocolloidal assembly and transport.

Graphical abstract: Directional migration propensity of calf thymus DNA in a gradient of metal ions

Supplementary files

Article information

Article type
Communication
Submitted
05 ذو القعدة 1443
Accepted
19 ذو الحجة 1443
First published
19 ذو الحجة 1443

Chem. Commun., 2022,58, 9353-9356

Directional migration propensity of calf thymus DNA in a gradient of metal ions

Shikha, E. Shandilya, Priyanka and S. Maiti, Chem. Commun., 2022, 58, 9353 DOI: 10.1039/D2CC03160D

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