Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments

Lei Gan; Miriam de J. Velásquez-Hernández; Anita Emmerstorfer-Augustin; Peter Wied; Heimo Wolinski; Simone Dal Zilio; Marcello Solomon; Weibin Liang; Christian Doonan; Paolo Falcaro

doi:10.1039/D2CC03072A

Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments†

Lei Gan,^a Miriam de J. Velásquez-Hernández,

^a Anita Emmerstorfer-Augustin,^b Peter Wied,

^a Heimo Wolinski,^c Simone Dal Zilio,^d Marcello Solomon,

^a Weibin Liang,^e Christian Doonan

*^e and Paolo Falcaro

*^a

Author affiliations

* Corresponding authors

^a Institute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, Austria
E-mail: paolo.falcaro@tugraz.at

^b Institute of Molecular Biotechnology, Graz University of Technology, NAWI Graz, BioTechMed-Graz,, Petergasse 14, Graz, Austria

^c Institute of Molecular Biosciences, BioTechMed-Graz, University of Graz, Graz, Austria

^d Istituto Officina dei Materiali CNR, Basovizza, Edificio MM-SS, Trieste, Italy

^e School of Physical Sciences, Faculty of Sciences, University of Adelaide, South Australia, Australia
E-mail: christian.doonan@adelaide.edu.au

Abstract

Metal–organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin).

This article is part of the themed collection: Emerging Trends in MOFs

Chemical Communications

Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments†

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Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments

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