Issue 57, 2022

Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues

Abstract

The site-selective chemical appendage of multiple functionalities on a native peptide backbone is a highly demanding and complex tool of modern chemical biology. Here, novel NHS-activated acrylates were designed to hold various payloads in a single bioconjugation handle that is able to site-selectively and orthogonally target the N-terminal cysteine of peptides.

Graphical abstract: Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues

Supplementary files

Article information

Article type
Communication
Submitted
17 رمضان 1443
Accepted
21 ذو القعدة 1443
First published
21 ذو القعدة 1443

Chem. Commun., 2022,58, 7928-7931

Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues

M. Djaló, M. J. S. A. Silva, H. Faustino, S. N. Pinto, R. Mendonça and P. M. P. Gois, Chem. Commun., 2022, 58, 7928 DOI: 10.1039/D2CC02204D

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