Issue 11, 2021

α-Oxygenation of N-aryl/alkyl heterocyclic compounds via ruthenium photocatalysis

Abstract

We herein report ruthenium(III) photocatalyzed oxidation of N-aryl tertiary amines to the corresponding amides. More specifically, various N-aryl tetrahydroisoquinolines were converted to analogous N-aryl dihydroisoquinolinones under an oxygen atmosphere. Molecular oxygen is utilized for α-oxidation in the presence of benzylic proton abstracting base DBU to get oxidized products in good to excellent yields. Quenching experiments confirmed the radical pathway of the reaction through the formation of O2˙ reactive oxygen species (ROS).

Graphical abstract: α-Oxygenation of N-aryl/alkyl heterocyclic compounds via ruthenium photocatalysis

Supplementary files

Article information

Article type
Paper
Submitted
07 شوال 1442
Accepted
26 ذو الحجة 1442
First published
09 محرم 1443

React. Chem. Eng., 2021,6, 2087-2091

α-Oxygenation of N-aryl/alkyl heterocyclic compounds via ruthenium photocatalysis

I. Kumar, A. Thakur, Manisha and U. Sharma, React. Chem. Eng., 2021, 6, 2087 DOI: 10.1039/D1RE00200G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements