Issue 22, 2021

A robust and facile method for desulfonation to amines

Abstract

In this study, a robust and facile method for desulfonation to achieve secondary amines is demonstrated. Diphenylphosphine (Ph2PH) was shown to significantly expedite the cleavage of sulfonamides under basic conditions. Aromatic and aliphatic sulfonamides were cleanly converted, with a rapid reaction time, into the required amines with good to excellent chemical yields. Moreover, the functional groups tested were generally well tolerated.

Graphical abstract: A robust and facile method for desulfonation to amines

Supplementary files

Article information

Article type
Research Article
Submitted
03 محرم 1443
Accepted
08 صفر 1443
First published
09 صفر 1443

Org. Chem. Front., 2021,8, 6182-6186

A robust and facile method for desulfonation to amines

C. Li, Y. Huang, S. Cao, Y. Luo, Y. Zhang and G. Yang, Org. Chem. Front., 2021, 8, 6182 DOI: 10.1039/D1QO01190A

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