Achievements in fluorination using variable reagents through a deoxyfluorination reaction

Abstract

The fusion of fluorine in drug molecules through different fluorinating reagents remains a cornerstone in pharmaceutical chemistry. Progress in the field of deoxyfluorination through the development of novel reagents has enabled new mechanistic approaches to achieve organic transformations. Methodologies for the incorporation of fluorine into a complex molecule continue to be an important area of research because of the presence of fluorine in a plethora of pharmaceutical active ingredients. In this review, we have summarized the 2011–2021 progress made in the area of deoxyfluorination for the construction of biologically active molecules. The synthetic strategies described in this review provided diversely substituted fluorinated molecules and a few of them have profound pharmacological activity.