Issue 22, 2021

Achievements in fluorination using variable reagents through a deoxyfluorination reaction

Abstract

The fusion of fluorine in drug molecules through different fluorinating reagents remains a cornerstone in pharmaceutical chemistry. Progress in the field of deoxyfluorination through the development of novel reagents has enabled new mechanistic approaches to achieve organic transformations. Methodologies for the incorporation of fluorine into a complex molecule continue to be an important area of research because of the presence of fluorine in a plethora of pharmaceutical active ingredients. In this review, we have summarized the 2011–2021 progress made in the area of deoxyfluorination for the construction of biologically active molecules. The synthetic strategies described in this review provided diversely substituted fluorinated molecules and a few of them have profound pharmacological activity.

Graphical abstract: Achievements in fluorination using variable reagents through a deoxyfluorination reaction

Article information

Article type
Review Article
Submitted
16 ذو القعدة 1442
Accepted
10 محرم 1443
First published
10 محرم 1443

Org. Chem. Front., 2021,8, 6452-6468

Achievements in fluorination using variable reagents through a deoxyfluorination reaction

T. Aggarwal, Sushmita and A. K. Verma, Org. Chem. Front., 2021, 8, 6452 DOI: 10.1039/D1QO00952D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements