Issue 5, 2021

Origami paper-based sample preconcentration using sequentially driven ion concentration polarization

Abstract

Ion concentration polarization (ICP) is one of the preconcentration techniques which can acquire a high preconcentration factor. Still, the main hurdles of ICP are its instability and low efficiency under physiological conditions with high ionic strength and abundant biomolecules. Here, we suggested a sequentially driven ICP process, which enhanced the electrokinetic force required for preconcentration, enabling enrichment of highly ionic raw samples without increasing the electric field. We acquired a 13-fold preconcentration factor (PF) in human serum using a paper-based origami structure consisting of multiple layers for three-dimensional sequential ICP (3D seq-ICP). Moreover, we demonstrated a paper-based enzyme-linked immunosorbent assay (ELISA) by 3D seq-ICP using tau protein, showing a 6-fold increase in ELISA signals.

Graphical abstract: Origami paper-based sample preconcentration using sequentially driven ion concentration polarization

Supplementary files

Article information

Article type
Paper
Submitted
27 صفر 1442
Accepted
03 جمادى الثانية 1442
First published
05 جمادى الثانية 1442

Lab Chip, 2021,21, 867-874

Origami paper-based sample preconcentration using sequentially driven ion concentration polarization

J. Lee, Y. K. Yoo, D. Lee, C. Kim, K. H. Kim, S. Lee, S. Kwak, J. Y. Kang, H. Kim, D. S. Yoon, D. Hur and J. H. Lee, Lab Chip, 2021, 21, 867 DOI: 10.1039/D0LC01032D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements