Issue 48, 2021

Biocompatible MOF-808 as an iodophor antimicrobial agent with controlled and sustained release of iodine

Abstract

In recent years, the increasing occurrence of microbial resistance to biocidal materials has become a serious problem. In contrast to other biocides, iodine seems to have no real resistance issue, but its instability causes pain and irritation. The metal–organic framework Zr6O4(OH)4(BTC)2(HCOO)6 (MOF-808) is a highly thermally and chemically stable Zr-MOF synthesized from trimesic acid (H3BTC). H3BTC is a highly electron-deficient molecule that seems to make MOF-808 an appropriate adsorbent of non-polar iodine. Herein, activated MOF-808 was synthesized for caging the biocide, iodine. The obtained samples were characterized by FT-IR spectroscopy, PXRD, TGA, SEM, TEM, ZP and BET analyses. The adsorbed amount of iodine on the iodine-loaded MOF-808 (I2@MOF-808) was estimated by thermogravimetric analyses (25.3%) and UV-vis spectroscopy (27.0%). Finally, its antibacterial activity was evaluated against S. aureus and E. coli with a reported 19 mm zone of inhibition for I2@MOF-808 against S. aureus. Therefore, I2@MOF-808 can be considered as a biocide that does not have the microbial resistance problem and also problems caused by the instability of iodine.

Graphical abstract: Biocompatible MOF-808 as an iodophor antimicrobial agent with controlled and sustained release of iodine

Supplementary files

Article information

Article type
Paper
Submitted
21 جمادى الأولى 1442
Accepted
18 ربيع الأول 1443
First published
20 ربيع الأول 1443

CrystEngComm, 2021,23, 8538-8545

Biocompatible MOF-808 as an iodophor antimicrobial agent with controlled and sustained release of iodine

M. Nakhaei, K. Akhbari and A. Davoodi, CrystEngComm, 2021, 23, 8538 DOI: 10.1039/D1CE00019E

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