Fluorometric discrimination of tyrosine isomers based on the inner filter effect of chiral Au nanoparticles on MoS2 quantum dots

Abstract

A fluorescent chiral sensor is proposed based on the inner filter effect (IFE) of chiral Au nanoparticles (AuNPs) on MoS₂ quantum dots (MoS₂ QDs), which can be used for the discrimination of the isomers of tyrosine (Tyr). L-Tyrosine (L-Tyr) can induce obvious agglomeration of the chiral AuNPs, leading to an attenuated IFE of the chiral AuNPs and greatly restored fluorescence of the MoS₂ QDs, and thus the enantioselective recognition of the Tyr isomers can be achieved. Also, L-Tyr but not D-Tyr induced agglomeration of the chiral AuNPs is confirmed by the larger association constant between L-Tyr and the chiral sensor.