Issue 47, 2020

White light-triggered zwitterionic polymer nanoparticles based on an AIE-active photosensitizer for photodynamic antimicrobial therapy

Abstract

Photodynamic antimicrobial therapy (PDAT) has received enormous attention due to its excellent spatiotemporal accuracy, non-invasiveness, and anti-multidrug resistance properties compared with chemotherapy. However, traditional PDAT methods possess numerous disadvantages, such as high dark toxicity, poor chemical stability, susceptibility to fluorescence quenching, and relatively low ROS efficiency in water. In this work, we successfully fabricated a type of pH-responsive zwitterionic polyurethane nano-micelle possessing great reactive oxygen species (ROS) generation efficiency due to the smaller singlet–triplet energy gap of its AIE PS moiety. This nano-system also has near-infrared bioimaging functionality, and can detect bacteria in real time. In addition, the hydrophilic zwitterionic polyurethanes plays a vital role in antifouling, enhancing biocompatibility and prolonging circulation time under normal conditions (pH 7.4). Under acidic conditions (pH 5.4), the zwitterionic moiety is suddenly protonated to enable positively charged nano-micelles to target the bacterial infection site, resulting in great antibacterial efficiency, which is superior to the existing PDAT method.

Graphical abstract: White light-triggered zwitterionic polymer nanoparticles based on an AIE-active photosensitizer for photodynamic antimicrobial therapy

Supplementary files

Article information

Article type
Paper
Submitted
04 صفر 1442
Accepted
05 ربيع الأول 1442
First published
06 ربيع الأول 1442

J. Mater. Chem. B, 2020,8, 10754-10763

White light-triggered zwitterionic polymer nanoparticles based on an AIE-active photosensitizer for photodynamic antimicrobial therapy

B. Ren, K. Li, Z. Liu, G. Liu and H. Wang, J. Mater. Chem. B, 2020, 8, 10754 DOI: 10.1039/D0TB02272A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements