Issue 48, 2020

A review of in vitro cell culture testing methods for bioactive glasses and other biomaterials for hard tissue regeneration

Abstract

Bioactive glasses are used to regenerate bone by a mechanism which involves surface degradation, the release of ions such as calcium, soluble silica and phosphate and the precipitation of a biomimetic apatite surface layer on the glass. One major area of bioactive glass research is the incorporation of therapeutically active ions to broaden the application range of these materials. When developing such new compositions, in vitro cell culture studies are a key part of their characterisation. However, parameters of cell culture studies vary widely, and depending on the intended use of bioactive glass compositions, different layouts, cell types and assays need to be used. The aim of this publication is to provide materials scientists, particularly those new to cell culture studies, with a tool for selecting the most appropriate assays to give insight into the properties of interest.

Graphical abstract: A review of in vitro cell culture testing methods for bioactive glasses and other biomaterials for hard tissue regeneration

Article information

Article type
Review Article
Submitted
22 شوال 1441
Accepted
04 ربيع الأول 1442
First published
24 ربيع الأول 1442

J. Mater. Chem. B, 2020,8, 10941-10953

A review of in vitro cell culture testing methods for bioactive glasses and other biomaterials for hard tissue regeneration

E. Jablonská, D. Horkavcová, D. Rohanová and D. S. Brauer, J. Mater. Chem. B, 2020, 8, 10941 DOI: 10.1039/D0TB01493A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements