Issue 10, 2020

Morphology, structure and cytotoxicity of dye-loaded lipid nanoparticles based on monoamine pillar[5]arenes

Abstract

Nanoscale lipid drug delivery systems are widely used due to their high efficiency and possibility to increase the drug bioavailability. The size, shape and morphology of these systems can significantly impact their activity. We report the synthesis of new amphiphilic pillar[5]arenes and their use for the preparation of solid lipid nanoparticles (SLN) dispersed in water. The encapsulation of fluorescent dyes (fluorescein, rhodamine B, rhodamine 6G) in the particles made it possible for the first time to obtain dye-loaded SLNs (SLN-Flu, SLN-RhB, SLN-Rh6G) with distinctive morphology and low toxicity to A549 cells. Thus, the discovery of this ability of amphiphilic pillar[5]arenes allows creating new targeted delivery systems with high-precision morphology and advantageous properties.

Graphical abstract: Morphology, structure and cytotoxicity of dye-loaded lipid nanoparticles based on monoamine pillar[5]arenes

Supplementary files

Article information

Article type
Research Article
Submitted
07 ذو الحجة 1441
Accepted
13 محرم 1442
First published
14 محرم 1442

Mater. Chem. Front., 2020,4, 2962-2970

Morphology, structure and cytotoxicity of dye-loaded lipid nanoparticles based on monoamine pillar[5]arenes

L. S. Yakimova, E. G. Guralnik, D. N. Shurpik, V. G. Evtugyn, Y. N. Osin, E. V. Subakaeva, E. A. Sokolova, P. V. Zelenikhin and I. I. Stoikov, Mater. Chem. Front., 2020, 4, 2962 DOI: 10.1039/D0QM00547A

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