Issue 34, 2020

Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation

Abstract

A Knoevenagel condensation of various aldehydes with malononitrile effectively proceeded in the presence of hydroquinone/benzoquinone mixed catalysts at room temperature in H2O. Furthermore, γ-deuterium-labeled α,β-unsaturated nitrile derivatives were also constructed via a deuteration of an aliphatic aldehyde in D2O using a basic resin and the subsequent Knoevenagel condensation.

Graphical abstract: Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation

Supplementary files

Article information

Article type
Communication
Submitted
16 ذو القعدة 1441
Accepted
22 ذو الحجة 1441
First published
23 ذو الحجة 1441

Org. Biomol. Chem., 2020,18, 6594-6597

Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation

R. Takakura, K. Koyama, M. Kuwata, T. Yamada, H. Sajiki and Y. Sawama, Org. Biomol. Chem., 2020, 18, 6594 DOI: 10.1039/D0OB01397H

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