Issue 48, 2020

Research advances in integrated theranostic probes for tumor fluorescence visualization and treatment

Abstract

At present, cancer is obviously a major threat to human health worldwide. Accurate diagnosis and treatment are in great demand and have become an effective method to alleviate the development of cancer and improve the survival rate of patients. A large number of theranostic probes that combine diagnosis and treatment methods have been developed as promising tools for tumor precision medicine. Among them, fluorescent theranostic probes have developed rapidly in the frontier research field of precision medicine with their real time, low toxicity, and high-resolution merit. Therefore, this review focuses on recent advances in the development of fluorescent theranostic probes, as well as their applications for cancer diagnosis and treatment. Initially, small-molecule fluorescent theranostic probes mainly including tumor microenvironment-responsive fluorescent prodrugs and phototherapeutic probes were introduced. Subsequently, nanocomposite probes are expounded based on four types of nano-fluorescent particles combining different therapies (chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, etc.). Then, the capsule-type “all in one” probes, which occupy an important position in theranostic probes, are summarized according to the surface carrier type. This review aims to present a comprehensive guide for researchers in the field of tumor-related theranostic probe design and development.

Graphical abstract: Research advances in integrated theranostic probes for tumor fluorescence visualization and treatment

Article information

Article type
Review Article
Submitted
07 صفر 1442
Accepted
29 ربيع الأول 1442
First published
01 ربيع الثاني 1442

Nanoscale, 2020,12, 24311-24330

Research advances in integrated theranostic probes for tumor fluorescence visualization and treatment

J. Xing, Q. Gong, O. U. Akakuru, C. Liu, R. Zou and A. Wu, Nanoscale, 2020, 12, 24311 DOI: 10.1039/D0NR06867E

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