Issue 1, 2020

Why we might be misusing process mass intensity (PMI) and a methodology to apply it effectively as a discovery level metric

Abstract

Process mass intensity (PMI) is a key mass-based metric to evaluate the green credentials of an individual or sequence of reactions during process and chemical development. The increasing awareness to consider greenness as early as the initial discovery level, requires a set of parameters suitable to assess it at this stage of development, and guidelines to apply them correctly. This paper evaluates when and how PMI can be used in a correct manner. Different simulations for key reactions in the organic synthesis toolbox – i.e. amide bond formation and Mitsunobu reactions – illustrate that PMI can easily be misleading without due consideration of yield, concentration and molecular weight of reactants and product. A fair appraisal of the green potential of different methodologies therefore requires careful analysis of the examples and metrics data generated.

Graphical abstract: Why we might be misusing process mass intensity (PMI) and a methodology to apply it effectively as a discovery level metric

Supplementary files

Article information

Article type
Paper
Submitted
03 رمضان 1440
Accepted
10 ربيع الأول 1441
First published
10 ربيع الأول 1441

Green Chem., 2020,22, 123-135

Why we might be misusing process mass intensity (PMI) and a methodology to apply it effectively as a discovery level metric

E. R. Monteith, P. Mampuys, L. Summerton, J. H. Clark, B. U. W. Maes and C. R. McElroy, Green Chem., 2020, 22, 123 DOI: 10.1039/C9GC01537J

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