Issue 9, 2019

Rapid route design of AZD7594

Abstract

A wide variety of technology platforms were used to rapidly select a commercial manufacturing route to the inhaled glucocorticoid receptor modulator AZD7594. This collaborative approach to the route design employed idea generation, high-throughput salt formation, solubility and chemical reaction screening, process analytical techniques and factorial experimental design to propose, assess and select the new strategic route within a five-month window. The selected route is currently undergoing further process development and optimisation and will be implemented in future manufacturing campaigns to supply drug substance for ongoing clinical studies and ultimately for the commercially marketed product.

Graphical abstract: Rapid route design of AZD7594

Supplementary files

Article information

Article type
Paper
Submitted
08 رجب 1440
Accepted
29 رمضان 1440
First published
02 شوال 1440

React. Chem. Eng., 2019,4, 1658-1673

Rapid route design of AZD7594

H. L. Carter, A. W. Connor, R. Hart, J. McCabe, A. C. McIntyre, A. E. McMillan, N. R. Monks, A. K. Mullen, T. O. Ronson, A. Steven, S. Tomasi and S. D. Yates, React. Chem. Eng., 2019, 4, 1658 DOI: 10.1039/C9RE00118B

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