Issue 77, 2019

A supramolecular sensor array for selective immunoglobulin deficiency analysis

Abstract

A host–guest based fluorescence sensor array can sense small differences in protein structure. The combination of three cavitand hosts and two fluorophores to form a 4-component array is sufficient to fully discriminate five structurally similar Ig protein isotypes. The array can be applied to recognize Ig deficiencies in serum, when combined with a Protein L-based extraction process, allowing analysis of immunodeficiency in a simpler, lower cost manner than tests that require multiple specific antibodies.

Graphical abstract: A supramolecular sensor array for selective immunoglobulin deficiency analysis

Supplementary files

Article information

Article type
Communication
Submitted
04 ذو الحجة 1440
Accepted
03 محرم 1441
First published
04 محرم 1441

Chem. Commun., 2019,55, 11563-11566

Author version available

A supramolecular sensor array for selective immunoglobulin deficiency analysis

Y. Liu, A. D. Gill, Y. Duan, L. Perez, R. J. Hooley and W. Zhong, Chem. Commun., 2019, 55, 11563 DOI: 10.1039/C9CC06064B

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