Issue 24, 2018

Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance

Abstract

Dendritic mesoporous silica nanoparticles (DMSNs) with a small diameter (∼50 nm) and a large pore size (>20 nm) have been synthesized at room temperature. It is shown that the choice of room temperature synthesis favours the formation of large-pore and small-size DMSNs compared to conventional synthesis at higher temperature. Compared to mesoporous silica nanoparticles with a similar particle size but a smaller mesopore size and DMSNs with a similar pore size but a larger particle size, DMSNs with both a small particle size and a large pore size possess a higher in vitro mRNA transfection efficiency, indicating their potential as promising delivery vehicles for exogenous genetic molecules.

Graphical abstract: Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance

Supplementary files

Article information

Article type
Paper
Submitted
11 جمادى الثانية 1439
Accepted
02 رمضان 1439
First published
02 رمضان 1439

J. Mater. Chem. B, 2018,6, 4089-4095

Author version available

Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance

Y. Wang, H. Song, M. Yu, C. Xu, Y. Liu, J. Tang, Y. Yang and C. Yu, J. Mater. Chem. B, 2018, 6, 4089 DOI: 10.1039/C8TB00544C

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