Issue 20, 2018

Iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling of primary benzamides with thiophenes

Abstract

(2-Thienyl)benzamide frameworks are prevalent in pharmaceuticals and advanced materials. Herein, we disclose an iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling reaction of primary benzamides with thiophenes, which provides a rapid pathway to (2-thienyl)benzamide skeletons. Furthermore, the coupled products can be transformed to the corresponding important thiophene-fused 1-isoquinolinones via a copper-catalyzed intramolecular annulation.

Graphical abstract: Iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling of primary benzamides with thiophenes

Supplementary files

Article information

Article type
Research Article
Submitted
18 ذو القعدة 1439
Accepted
26 ذو الحجة 1439
First published
26 ذو الحجة 1439

Org. Chem. Front., 2018,5, 2930-2933

Iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling of primary benzamides with thiophenes

G. Tan, C. Ran and J. You, Org. Chem. Front., 2018, 5, 2930 DOI: 10.1039/C8QO00796A

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