Issue 11, 2018

Synthetic, small-molecule photoantimicrobials – a realistic approach

Abstract

The search for suitable, low-molecular weight photoantimicrobials for use in infection control has strong foundations in conventional antiseptic research from the early-mid 20th Century. Many examples of dyes exist having conventional antimicrobial activity among the azine, acridine and triphenylmethane families which have since also been found to exhibit photosensitising capabilities. The prior employment of these examples in human antisepsis provides a practical basis in terms of low host toxicity, while extant structure–activity relationships for conventional antimicrobial activity can support the development of similar relationships for photoactivated cell killing. The range of chromophores covered allows progress to be made both in topical and deeper, fluid-involved infections.

Graphical abstract: Synthetic, small-molecule photoantimicrobials – a realistic approach

Article information

Article type
Paper
Submitted
20 رجب 1439
Accepted
24 رمضان 1439
First published
27 رمضان 1439

Photochem. Photobiol. Sci., 2018,17, 1767-1779

Synthetic, small-molecule photoantimicrobials – a realistic approach

M. Wainwright, Photochem. Photobiol. Sci., 2018, 17, 1767 DOI: 10.1039/C8PP00145F

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