Issue 1, 2018

Size controllable DNA nanogels from the self-assembly of DNA nanostructures through multivalent host–guest interactions

Abstract

Nanogels made of biomolecules are one of the potential candidates as a nanocarrier for drug delivery applications. The unique structural characteristics and excellent biocompatibility of DNA suggest that DNA nanogels would be an ideal candidate. Herein, a general design strategy for the crafting of DNA nanogels with controllable size using the multivalent host–guest interaction between β-CD functionalized branched DNA nanostructures as the host and a star-shaped adamantyl-terminated 8-arm poly(ethylene glycol) polymer as the guest is reported. Our results reveal that multivalent host–guest interactions are necessary for the nanogel formation. Nanogels exhibit excellent biocompatibility, good cell permeability and high drug encapsulation ability, which are promising features for their application as a drug carrier. The encapsulation of doxorubicin, an anticancer drug, inside the hydrophobic network of the nanogel and its delivery into cancer cells are also reported. We hope that the general design strategy demonstrated for the creation of DNA nanogels may encourage other researchers to use this approach for the design of DNA nanogels of other DNA nanostructures, and explore the potential of DNA nanogels in drug delivery applications.

Graphical abstract: Size controllable DNA nanogels from the self-assembly of DNA nanostructures through multivalent host–guest interactions

Supplementary files

Article information

Article type
Paper
Submitted
28 ذو الحجة 1438
Accepted
03 ربيع الأول 1439
First published
05 ربيع الأول 1439

Nanoscale, 2018,10, 222-230

Size controllable DNA nanogels from the self-assembly of DNA nanostructures through multivalent host–guest interactions

H. V. P. Thelu, S. K. Albert, M. Golla, N. Krishnan, D. Ram, S. M. Srinivasula and R. Varghese, Nanoscale, 2018, 10, 222 DOI: 10.1039/C7NR06985E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements