Issue 63, 2018

Copper-mediated intramolecular aminofluorination of 1,3-dienes by using nucleophilic fluorine reagents

Abstract

A copper-mediated intramolecular aminofluorination of 1,3-dienes is disclosed, in which both AgF and Et3N·3HF can be used as the fluorine source. This protocol provides a variety of pyrrolidines bearing allylic fluorides with excellent regioselectivities and good diastereoselectivities.

Graphical abstract: Copper-mediated intramolecular aminofluorination of 1,3-dienes by using nucleophilic fluorine reagents

Supplementary files

Article information

Article type
Communication
Submitted
06 شوال 1439
Accepted
27 شوال 1439
First published
27 شوال 1439

Chem. Commun., 2018,54, 8709-8712

Copper-mediated intramolecular aminofluorination of 1,3-dienes by using nucleophilic fluorine reagents

Z. Zhang, P. Chen and G. Liu, Chem. Commun., 2018, 54, 8709 DOI: 10.1039/C8CC04909B

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