Issue 12, 2017

Mononuclear palladium(ii) and platinum(ii) complexes of P,C-donor ligands: synthesis, crystal structures, cytotoxicity, and mechanistic studies of a highly stereoselective Mizoroki–Heck reaction

Abstract

Cyclometalated Pd(II) and Pt(II) complexes of unsymmetrical phosphonium ylides Ph2P(CH2)nPPh2[double bond, length as m-dash]C(H)C(O)C6H4R (R = Ph, n = 2 (Y1); R = NO2, n = 1 (Y2)) have been prepared through a simple procedure to explore new directions in stereoselective catalysis and antitumor metallodrugs. The new pallada- and platinacycle complexes have been characterized by spectroscopic, crystallographic, and density functional theory methods. Catalytic activity and in vitro cytotoxicity of these compounds, as assessed, respectively, using the Mizoroki–Heck reaction and a human tumor cell line, have been evaluated. In particular, a mechanistic pathway of the Heck reaction catalyzed by Pd(II) complex (1) with a chelating P,C- ligand has been investigated by DFT studies. The computational results were in agreement with those of experiments, which demonstrate the high stereoselectivity in the Pd-catalyzed Csp2–Csp2 cross coupling reaction and the origin of an observed coordination mode in the prepared complexes. In this article, the cytotoxicity effects of four-coordinated Pt(II) complex (2) against MCF-7 cells clearly reveal its great potential as an antitumor agent.

Graphical abstract: Mononuclear palladium(ii) and platinum(ii) complexes of P,C-donor ligands: synthesis, crystal structures, cytotoxicity, and mechanistic studies of a highly stereoselective Mizoroki–Heck reaction

Supplementary files

Article information

Article type
Research Article
Submitted
24 ذو الحجة 1438
Accepted
23 محرم 1439
First published
17 صفر 1439

Inorg. Chem. Front., 2017,4, 2107-2118

Mononuclear palladium(II) and platinum(II) complexes of P,C-donor ligands: synthesis, crystal structures, cytotoxicity, and mechanistic studies of a highly stereoselective Mizoroki–Heck reaction

S. J. Sabounchei, M. Hosseinzadeh, S. Salehzadeh, F. Maleki and R. W. Gable, Inorg. Chem. Front., 2017, 4, 2107 DOI: 10.1039/C7QI00568G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements