Issue 6, 2017

Catalyst-free N-methylation of amines using CO2

Abstract

Recently, utilizing CO2 as a methylation reagent to construct functional chemicals has attracted significant attention. However, the conversion of CO2 is still a challenge due to its inherent inertness. In this study, we have developed a catalyst-free N-methylation of amines to prepare numerous methylamines using CO2 as a methyl source. By utilizing 2 eq. PhSiH3 as the reductant, amines could undergo N-methylation under 1 atm of CO2 in DMF at 90 °C. Aliphatic and aromatic amines were compatible, generating the desired products in up to 95% yield.

Graphical abstract: Catalyst-free N-methylation of amines using CO2

Supplementary files

Article information

Article type
Communication
Submitted
14 صفر 1438
Accepted
18 ربيع الأول 1438
First published
20 ربيع الأول 1438

Chem. Commun., 2017,53, 1148-1151

Catalyst-free N-methylation of amines using CO2

H. Niu, L. Lu, R. Shi, C. Chiang and A. Lei, Chem. Commun., 2017, 53, 1148 DOI: 10.1039/C6CC09072A

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