Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

X. Luo; W. Wang; J. R. Dorkin; O. Veiseh; P. H. Chang; I. Abutbul-Ionita; D. Danino; R. Langer; D. G. Anderson; Y. Dong

doi:10.1039/C6BM00683C

Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo†

X. Luo,‡^a W. Wang,‡^bc J. R. Dorkin,^d O. Veiseh,^bce P. H. Chang,^bc I. Abutbul-Ionita,^f D. Danino,^f R. Langer,^bceg D. G. Anderson*^bceg and Y. Dong*^ahij

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* Corresponding authors

^a Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
E-mail: dong.525@osu.edu

^b David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
E-mail: dgander@mit.edu

^c Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA

^d Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

^e Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

^f Department of Biotechnology and Food Engineering, Technion Institute of Technology and the Russell Berrie Nanotechnology Institute, Haifa 32000, Israel

^g Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

^h Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA

ⁱ The Center for Clinical and Translational Science, The Ohio State University, Columbus, OH 43210, USA

^j The Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA

Abstract

Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

This article is part of the themed collection: Biomaterials Science Lectureship Winners

Biomaterials Science

Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo†

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Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

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