Issue 9, 2016

Materials design at the interface of nanoparticles and innate immunity

Abstract

Engineered nanoparticle platforms have been developed intensely in recent years, yielding significantly broadened applications from interrogating novel biology to new therapies. The mammalian immune system has emerged as perhaps the most powerful physiological system where nanoparticle design parameters have drastic implications for nanoparticle fate and function. In particular, the innate immune system is a major concern due to its role as the first-line defense against foreign invaders, responsible for initiating and maintaining the innate immune response as well as priming the adaptive immune response. Understanding how nanoparticles are perceived from a biological perspective is crucial to informing their design with different immunogenic, immunosuppressive, or stealth properties. Nanoparticles are particularly susceptible to innate immune responses such as opsonization and recognition by receptors that enable phagocytic uptake or evoke strong inflammatory responses due to the recognition of various “danger” signals. In this review, we will summarize some of the key advances in our understanding of how physical and biochemical parameters of nanoparticles interact with innate immunity, and note potential opportunities and emerging frontiers for controlling and evaluating nanoparticle–immune interactions.

Graphical abstract: Materials design at the interface of nanoparticles and innate immunity

Article information

Article type
Review Article
Submitted
19 ذو القعدة 1436
Accepted
17 ربيع الثاني 1437
First published
19 ربيع الثاني 1437

J. Mater. Chem. B, 2016,4, 1610-1618

Author version available

Materials design at the interface of nanoparticles and innate immunity

G. L. Szeto and E. B. Lavik, J. Mater. Chem. B, 2016, 4, 1610 DOI: 10.1039/C5TB01825K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements