Issue 9, 2016

Biomolecular strategies to modulate the macrophage response to implanted materials

Abstract

The material-induced foreign body response is a major challenge for implanted medical devices. This review highlights recent developments in biomimetic approaches to create biomaterials that mitigate the host response to biomaterials. Specifically, we will describe strategies in which biomaterials are decorated with endogenously expressed biomolecules that naturally modulate the function of immune cells. These include molecules that directly bind to and interact with immune cells, as well as molecules that control complement activation or thrombosis and indirectly modulate immune cell function. We provide perspective on how these approaches may impact the design of materials for medical devices and tissue engineering.

Graphical abstract: Biomolecular strategies to modulate the macrophage response to implanted materials

Article information

Article type
Review Article
Submitted
22 شوال 1436
Accepted
24 ذو القعدة 1436
First published
25 ذو القعدة 1436

J. Mater. Chem. B, 2016,4, 1600-1609

Biomolecular strategies to modulate the macrophage response to implanted materials

Y. K. Kim, E. Y. Chen and W. F. Liu, J. Mater. Chem. B, 2016, 4, 1600 DOI: 10.1039/C5TB01605C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements