Next-generation disulfide stapling: reduction and functional re-bridging all in one

Maximillian T. W. Lee; Antoine Maruani; James R. Baker; Stephen Caddick; Vijay Chudasama

doi:10.1039/C5SC02666K

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Next-generation disulfide stapling: reduction and functional re-bridging all in one†

Maximillian T. W. Lee,^a Antoine Maruani,^a James R. Baker,^a Stephen Caddick^a and Vijay Chudasama

*^a

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^a Department of Chemistry, University College London, 20 Gordon Street, London, United Kingdom
E-mail: v.chudasama@ucl.ac.uk
Tel: +44207 679 2077

Abstract

Herein we present a significant step towards next-generation disulfide stapling reagents. A novel class of reagent has been designed to effect both disulfide reduction and functional re-bridging. The strategy has been applied to great success across various peptides and proteins. Moreover, application to a multi-disulfide system resulted in functional re-bridging without disulfide scrambling.

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DOI: https://doi.org/10.1039/C5SC02666K
Article type: Edge Article
Submitted: 06 شوال 1436
Accepted: 29 ذو القعدة 1436
First published: 02 ذو الحجة 1436
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry

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Chem. Sci., 2016,7, 799-802

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Next-generation disulfide stapling: reduction and functional re-bridging all in one

M. T. W. Lee, A. Maruani, J. R. Baker, S. Caddick and V. Chudasama, Chem. Sci., 2016, 7, 799 DOI: 10.1039/C5SC02666K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Chemical Science

Next-generation disulfide stapling: reduction and functional re-bridging all in one†

Abstract

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Next-generation disulfide stapling: reduction and functional re-bridging all in one

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