Issue 62, 2016

Ir(iii)-catalyzed synthesis of isoquinolines from benzimidates and α-diazocarbonyl compounds

Abstract

We report herein a tandem Ir(III)-catalyzed C–H activation and annulation reaction for the synthesis of isoquinolines by using readily available substituted benzimidates and α-diazocarbonyl compounds under mild conditions. The catalytic reaction exhibits excellent tolerance to different functional groups and the corresponding isoquinolines were obtained in good to excellent yields. This novel method affords an alternative strategy for the construction of diverse and useful isoquinoline derivatives.

Graphical abstract: Ir(iii)-catalyzed synthesis of isoquinolines from benzimidates and α-diazocarbonyl compounds

Supplementary files

Article information

Article type
Communication
Submitted
11 رجب 1437
Accepted
26 شعبان 1437
First published
03 رمضان 1437

RSC Adv., 2016,6, 57371-57374

Ir(III)-catalyzed synthesis of isoquinolines from benzimidates and α-diazocarbonyl compounds

X. Yang, J. Jie, H. Li and M. Piao, RSC Adv., 2016, 6, 57371 DOI: 10.1039/C6RA10045G

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