Issue 26, 2016

HPLC enantioseparation on a homochiral MOF–silica composite as a novel chiral stationary phase

Abstract

The last frontier in the development of chiral stationary phases for chromatographic enantioseparation involves homochiral metal–organic frameworks (MOFs). Using enantiopure (R)-2,2′-dihydroxy-1,1′-binaphthalene-6,6′-dicarboxylic acid as a starting material, we prepared three homochiral MOFs that were further used as chiral stationary phases for high-performance liquid chromatography to separate the enantiomers of various kinds of racemic sulfoxides, sec-alcohols, β-lactams, benzoins, flavanones and epoxides. The experimental results showed excellent performances for enantioseparation, and highlighted that enantioseparation on homochiral MOF columns is practical.

Graphical abstract: HPLC enantioseparation on a homochiral MOF–silica composite as a novel chiral stationary phase

Supplementary files

Article information

Article type
Paper
Submitted
01 ربيع الأول 1437
Accepted
06 جمادى الأولى 1437
First published
07 جمادى الأولى 1437

RSC Adv., 2016,6, 21293-21301

HPLC enantioseparation on a homochiral MOF–silica composite as a novel chiral stationary phase

K. Tanaka, T. Muraoka, Y. Otubo, H. Takahashi and A. Ohnishi, RSC Adv., 2016, 6, 21293 DOI: 10.1039/C5RA26520G

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