The recognition of human growth hormone (hGH) by the synthetic host molecule cucurbit[7]uril (Q7) was predicted on the basis of its N-terminal phenylalanine. An aqueous-compatible resin with covalently immobilized Q7 groups was prepared and shown to recognize native insulin and hGH in simple and complex mixtures.
![Graphical abstract: Predictive recognition of native proteins by cucurbit[7]uril in a complex mixture](/ar/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C6CC03193E&imageInfo.ImageIdentifier.Year=2016)
W. Li, A. T. Bockus, B. Vinciguerra, L. Isaacs and A. R. Urbach, Chem. Commun., 2016, 52, 8537 DOI: 10.1039/C6CC03193E
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