Issue 5, 2015

Selective NaOH-catalysed hydration of aromatic nitriles to amides

Abstract

The selective synthesis of aromatic and heteroaromatic amides through base-catalysed hydration of nitriles was achieved using inexpensive and commercially available NaOH as the only catalyst. A wide range of nitriles was selectively converted to their corresponding amides. Kinetic studies show that the double hydration of nitriles towards undesirable carboxylic acids is negligible under our reaction conditions.

Graphical abstract: Selective NaOH-catalysed hydration of aromatic nitriles to amides

Supplementary files

Article information

Article type
Paper
Submitted
12 جمادى الأولى 1436
Accepted
27 جمادى الأولى 1436
First published
04 جمادى الثانية 1436

Catal. Sci. Technol., 2015,5, 2865-2868

Selective NaOH-catalysed hydration of aromatic nitriles to amides

T. E. Schmid, A. Gómez-Herrera, O. Songis, D. Sneddon, A. Révolte, F. Nahra and C. S. J. Cazin, Catal. Sci. Technol., 2015, 5, 2865 DOI: 10.1039/C5CY00313J

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