Issue 19, 2015

The development of paper microfluidic devices for presumptive drug detection

Abstract

A paper microfluidic device has been developed for the presumptive testing of seized drugs in forensic casework. The procedure involves creating hydrophilic channels on chromatographic paper using wax printing and thermal lamination. The channels are connected to a single stem that draws an unknown analyte solution up into 6 different lanes. A different colorimetric reaction occurs within each lane, permitting the multiplexed detection of a variety of different compounds, including cocaine, opiates, ketamine, and various phenethyl amines. Furthermore, the linear orientation of the lanes permits series of reactants to be placed in each channel, enhancing stability and permitting sequential interaction with the analyte as the solvent front passes through each individual reagent. The resultant device was characterized for sensitivity and tested with a variety of common interferences and drug diluents. It should prove a useful device for screening seized drugs.

Graphical abstract: The development of paper microfluidic devices for presumptive drug detection

Associated articles

Article information

Article type
Paper
Submitted
16 شعبان 1436
Accepted
20 شوال 1436
First published
22 شوال 1436

Anal. Methods, 2015,7, 8025-8033

Author version available

The development of paper microfluidic devices for presumptive drug detection

G. Musile, L. Wang, J. Bottoms, F. Tagliaro and B. McCord, Anal. Methods, 2015, 7, 8025 DOI: 10.1039/C5AY01432H

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