Issue 11, 2015

Real-time monitoring of H2O2 release from single cells using nanoporous gold microelectrodes decorated with platinum nanoparticles

Abstract

Here, we report a self-supported nanoporous gold microelectrode decorated with well-dispersed and tiny platinum nanoparticles as an electrochemical nonenzymatic hydrogen peroxide biosensor. Nanoporous gold was fabricated by electrochemical alloying/dealloying and then small-sized platinum nanoparticles were electrodeposited uniformly on them. This novel hybrid nanostructure endows the sensor with high sensitivity and selectivity towards the reduction of hydrogen peroxide with a low detection limit of 0.3 nM. The sensor has been successfully applied for the measurement of H2O2 release from a single isolated human breast cancer cell, demonstrating its great potential for further physiological and pathological applications.

Graphical abstract: Real-time monitoring of H2O2 release from single cells using nanoporous gold microelectrodes decorated with platinum nanoparticles

Supplementary files

Article information

Article type
Paper
Submitted
15 محرم 1436
Accepted
19 ربيع الأول 1436
First published
21 ربيع الأول 1436

Analyst, 2015,140, 3753-3758

Author version available

Real-time monitoring of H2O2 release from single cells using nanoporous gold microelectrodes decorated with platinum nanoparticles

C. Xiao, Y. Liu, J. Xu, S. Lv, S. Guo and W. Huang, Analyst, 2015, 140, 3753 DOI: 10.1039/C4AN02056A

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