Synthesis of well-defined hydrogel networks using Click chemistry

Michael Malkoch; Robert Vestberg; Nalini Gupta; Laetitia Mespouille; Philipe Dubois; Andrew F. Mason; James L. Hedrick; Qi Liao; Curtis W. Frank; Kevin Kingsbury; Craig J. Hawker

doi:10.1039/B603438A

Synthesis of well-defined hydrogel networks using Click chemistry†

Michael Malkoch,^a Robert Vestberg,^a Nalini Gupta,^a Laetitia Mespouille,^bc Philipe Dubois,^c Andrew F. Mason,^b James L. Hedrick,*^b Qi Liao,^d Curtis W. Frank,^d Kevin Kingsbury^e and Craig J. Hawker*^a

Author affiliations

* Corresponding authors

^a Materials Research Laboratory (MRL), University of California, Santa Barbara, California 93106, USA
E-mail: hawker@mrl.ucsb.edu

^b IBM Almaden Research Center, 650 Harry Road, San Jose, California 95120, USA
E-mail: hedrick@almaden.ibm.com

^c Laboratory of Polymeric and Composite Materials (LPCM), University of Mons-Hainaut, Place du Parc 20, Belgium

^d Department of Chemical Engineering, Stanford University, Stanford, California 94305, USA

^e Department of Chemistry and Biochemistry, California Polytechnic State University, San Luis Obispo, California 93407, USA

Abstract

New PEG-based hydrogel materials have been synthesized by Click chemistry and shown to result in well-defined networks having significantly improved mechanical properties; the selectivity of the azide/acetylene coupling reaction also allows for the incorporation of various additives and functional groups leading to chemical tailoring of the hydrogels.

This article is part of the themed collection: ChemComm 60th Anniversary Historic Papers from North America

Chemical Communications

Synthesis of well-defined hydrogel networks using Click chemistry†

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Synthesis of well-defined hydrogel networks using Click chemistry

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