Issue 48, 2024

Quinoline-based tetrazolium prochelators: formazan release, iron sequestration, and antiproliferative efficacy in cancer cells

Abstract

Iron-binding strategies in anticancer drug design target the key role of iron in cancer growth. The incorporation of a quinoline moiety in the design of tetrazolium-based prochelators facilitates their intracellular reduction/activation to iron-binding formazans. The new prochelators are antiproliferative at submicromolar levels, induce apoptosis and cell cycle arrest, and impact iron signaling in cancer cells.

Graphical abstract: Quinoline-based tetrazolium prochelators: formazan release, iron sequestration, and antiproliferative efficacy in cancer cells

Supplementary files

Article information

Article type
Communication
Submitted
24 رمضان 1445
Accepted
12 ذو القعدة 1445
First published
20 ذو القعدة 1445

Chem. Commun., 2024,60, 6150-6153

Quinoline-based tetrazolium prochelators: formazan release, iron sequestration, and antiproliferative efficacy in cancer cells

Y. Sung and E. Tomat, Chem. Commun., 2024, 60, 6150 DOI: 10.1039/D4CC01523A

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