Issue 64, 2023

Pd-catalyzed regioselective rollover dual C–H annulation cascade: facile approach to phenanthrene derivatives

Abstract

Annulations of unsaturated systems through C–H activation represent a powerful tool for producing multicyclic scaffolds. Having coordinating centers in both annulation partners (a dual coordination strategy) would afford remarkable selectivities in the outcomes. Along this concept, we report herein a Pd-catalyzed regioselective rollover cascade dual C–H annulation of o-arylphenols with alkynols for constructing phenanthrene scaffolds. Control, KIE and deuteration studies were conducted to determine the reaction mechanism, and downstream transformations and scaled-up reactions were carried out to assess the robustness of the transformation.

Graphical abstract: Pd-catalyzed regioselective rollover dual C–H annulation cascade: facile approach to phenanthrene derivatives

Supplementary files

Article information

Article type
Communication
Submitted
05 ذو القعدة 1444
Accepted
12 ذو الحجة 1444
First published
13 ذو الحجة 1444

Chem. Commun., 2023,59, 9714-9717

Pd-catalyzed regioselective rollover dual C–H annulation cascade: facile approach to phenanthrene derivatives

M. N. Kumar, V. Suresh, A. Nagireddy, J. B. Nanubolu and M. S. Reddy, Chem. Commun., 2023, 59, 9714 DOI: 10.1039/D3CC02523C

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