Issue 5, 2022

Coordination-assisted, transition-metal-catalyzed enantioselective desymmetric C–H functionalization

Abstract

Transition-metal-catalyzed asymmetric C–H functionalization has gradually emerged as a powerful tool for the creation of structural and chiral complexity in an atom- and step-economical fashion. The nature of this strategy provides a variety of methodologies to overcome the limitation of enantioselective desymmetrization caused by the synthesis of preformed multifunctional symmetric substrates. This review aims to summarise recent advances in transition-metal-catalyzed enantioselective desymmetric C–H functionalization reactions via coordination-assisted metal insertion, covering the literature from 2008 to June 2021. The mechanistic pathway and the modes of stereocontrol are discussed where appropriate.

Graphical abstract: Coordination-assisted, transition-metal-catalyzed enantioselective desymmetric C–H functionalization

Article information

Article type
Review Article
Submitted
14 جمادى الأولى 1443
Accepted
03 جمادى الثانية 1443
First published
04 جمادى الثانية 1443

Org. Chem. Front., 2022,9, 1458-1484

Coordination-assisted, transition-metal-catalyzed enantioselective desymmetric C–H functionalization

X. Yu, Z. Zhang, J. Niu and B. Shi, Org. Chem. Front., 2022, 9, 1458 DOI: 10.1039/D1QO01884A

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