Issue 44, 2021

Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.

Abstract

Two new quassinoids (1 and 2) were isolated from the twigs of Harrisonia perforata (Blanco) Merr. Perforalactone E (2) possesses an uncommon hexacyclic 1α,12α:5α,13α-dicyclo-9βH-picrasane skeleton. Its structure was determined based on spectroscopic data and X-ray crystallography. Compounds 1 and 2 could significantly induce lysosomal biogenesis through transcriptional activation of lysosomal genes.

Graphical abstract: Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.

Supplementary files

Article information

Article type
Communication
Submitted
22 صفر 1443
Accepted
14 ربيع الأول 1443
First published
14 ربيع الأول 1443

Org. Biomol. Chem., 2021,19, 9637-9640

Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.

S. Liu, C. Zhang, X. Ran, X. Tang, Y. Guo, Y. Yan, Y. Yao, X. Hao, R. Luo and Y. Di, Org. Biomol. Chem., 2021, 19, 9637 DOI: 10.1039/D1OB01927A

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