Issue 14, 2020
From the journal:

Dalton Transactions

A tri-metallic palladium complex with breast cancer stem cell potency†

Arvin Eskandari,‡a   Arunangshu Kundu,‡b   Alice Johnson, ORCID logo c   Sanjib Karmakar,b   Sushobhan Ghosh ORCID logo *b  and  Kogularamanan Suntharalingam ORCID logo *c  

* Corresponding authors

a School of Pharmacy, University College London, London, UK

b Department of Chemistry, Gauhati University, Guwahati, India
E-mail: sushobhan.iisc@gmail.com

c School of Chemistry, University of Leicester, Leicester, UK
E-mail: k.suntharalingam@leicester.ac.uk

Abstract

A multi-nuclear, triangular-shaped palladium(II) complex is shown to equipotently kill bulk cancer cells and cancer stem cells (CSCs) in the micromolar range. The palladium(II) complex evokes CSC apoptosis by entering CSC nuclei and damaging genomic DNA.

Graphical abstract: A tri-metallic palladium complex with breast cancer stem cell potency

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0DT00006J
Article type
Communication
Submitted
06 جمادى الأولى 1441
Accepted
12 رجب 1441
First published
14 رجب 1441

Dalton Trans., 2020,49, 4211-4215

Permissions

Request permissions

A tri-metallic palladium complex with breast cancer stem cell potency

A. Eskandari, A. Kundu, A. Johnson, S. Karmakar, S. Ghosh and K. Suntharalingam, Dalton Trans., 2020, 49, 4211 DOI: 10.1039/D0DT00006J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements